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Genes Associated with Calcium Signaling are Involved in Alcohol-Induced Breast Cancer Growth.

Charles Ho1, Chin-Yo Lin1

  • 1From the, Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Science & Engineering Research Center, Houston, Texas, USA.

Alcoholism, Clinical and Experimental Research
|November 22, 2020
PubMed
Summary

Alcohol consumption significantly impacts breast cancer by altering gene expression related to calcium signaling. This impacts cell growth and disease progression, highlighting a critical link between alcohol and cancer development.

Keywords:
AlcoholismBreast CancerCalciumCistromeNFATC3

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Alcohol consumption is a known risk factor for breast cancer, linked to increased tumor aggressiveness and metastatic potential.
  • Mechanistic studies indicate alcohol influences angiogenesis, inflammation, and gene expression, including estrogen signaling in breast cancer cells.

Purpose of the Study:

  • To elucidate the mechanisms by which alcohol affects breast cancer.
  • To identify specific pathways and genes mediating alcohol's transcriptomic effects in breast cancer cells.

Main Methods:

  • Secondary analysis of alcohol-responsive transcriptome data using gene ontology and pathway analysis.
  • Cistromic data analysis to identify mediating transcription factors.
  • Experimental perturbation of predicted pathways in breast cancer cells and analysis of patient data.

Main Results:

  • Alcohol alters expression of metabolism-related genes and implicates nuclear factor of activated T cells 3 (NFATC3).
  • Alcohol regulates calcium signaling pathways, and chemical intervention reversed alcohol's effects on cell growth and calcium levels.
  • Alcohol-responsive genes correlate with poor disease outcomes and differ between drinkers and non-drinkers.

Conclusions:

  • Alcohol consumption alters gene expression controlling intracellular calcium levels and downstream signaling pathways.
  • These alterations in calcium signaling contribute to breast cancer cell proliferation and disease progression.