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Updated: Nov 29, 2025
Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
Published on: July 25, 2025
Changes of MRI in inter-spinal distraction fusion for lumbar degenerative disease: A retrospective analysis covering
Ruideng Wang1, Xiang Ji1, Lijia Liu1
1Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, No 95, Yong'an Road, Xicheng District, Beijing 100050, China.
Objective:
To assess the preoperative and postoperative changes in MRI image and the short-term efficacy of the ISDF with BacFuse covering 3 years.
Methods:
32 patients who underwent ISDF were involved in this retrospective study. The symptoms assessment including VAS, ODI, and SF-12 were evaluated preoperative and postoperative at 1 year and 3 years. The X-ray was used to measure posterior disk height (PDH), foramina height (FH), foramina width (FW), and MRI was taken to assess the cross-sectional area of dura sac (CSADS), cross-sectional area of canal (CSAC), herniated disc area, ligamentum flavum area. The preoperative ratio of herniated disc area and ligamentum flavum area to CSAC were compared with post-operative ratio. The modified Pfirrmann grade system was used to assess the surgical lumbar disc.
Results:
The symptom indexes were significantly improved after surgery. PDH and FH increased significantly (P < 0.05) after surgery compared with that before surgery, but there was no statistical difference in FW (P > 0.05). CSADS and CSAC increased obviously (P < 0.05), while the area of herniated disc and ligamentum flavum decreased significantly (P < 0.05). The ratio changes showed a significant difference between last follow-up and pre-operation (P < 0.05), but there was no statistical significance in grade changes of surgical disc.
Conclusion:
ISDF with BacFuse could relieve clinical symptoms and expanse the spinal canal area in MRI. During 3-year observation, it could provide continuous traction and maintain the area of spinal canal, so as to partially retract the herniated disc and make it possible to repair the disc.
Insights
Interbody Spinal Fusion (ISDF) with BacFuse effectively relieves pain and improves spinal canal dimensions on MRI. This 3-year study shows sustained benefits, including reduced herniated disc size and improved patient outcomes.
Area of Science:
- Spinal surgery
- Orthopedic surgery
- Neurosurgery
Background:
- Degenerative disc disease and herniated discs cause significant pain and neurological deficits.
- Interbody Spinal Fusion (ISDF) is a surgical option for spinal instability and disc degeneration.
- The BacFuse device is a novel implant used in ISDF procedures.
Purpose of the Study:
- To evaluate the short-term efficacy and MRI changes following ISDF with BacFuse.
- To assess the impact of ISDF with BacFuse on spinal canal dimensions and clinical outcomes over 3 years.
Main Methods:
- A retrospective study of 32 patients who underwent ISDF with BacFuse.
- Preoperative and 1- and 3-year postoperative assessments included VAS, ODI, and SF-12 scores.
- Radiographic measurements (X-ray and MRI) evaluated spinal height, canal area, and disc/ligamentum flavum size.
Main Results:
- Significant improvements in pain and functional scores (VAS, ODI, SF-12) were observed post-surgery.
- ISDF with BacFuse led to increased posterior disk height and foramina height.
- MRI showed significant expansion of the dural sac and spinal canal area, with reduced herniated disc and ligamentum flavum size.
Conclusions:
- ISDF with BacFuse effectively alleviates clinical symptoms and expands spinal canal dimensions.
- The procedure provides sustained spinal canal area maintenance over 3 years.
- BacFuse facilitates partial herniated disc retraction, potentially aiding disc repair.
