Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain barriers as checkpoints in endocrine regulation of body homeostasis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

<i>GCH1</i> p.Ser80Asn Confers Risk for Parkinson's Disease in East Asian Populations.

medRxiv : the preprint server for health sciences·2026
Same author

Cross-shore heterogeneity in organic carbon storage and source composition in bare tidal flats of South Korea.

Marine pollution bulletin·2026
Same author

Serum Neuronal Extracellular vesicles for RT-QuIC assay to detect Pathological α-Synuclein in Synucleinopathies.

Journal of movement disorders·2026
Same author

Corrigendum to "Polystyrene nanoplastics modulate neurite length in a size-specific manner" [Nanoimpact, Volume 41 (2026), 100614].

NanoImpact·2026
Same author

Brain Barriers in Normal Pressure Hydrocephalus: Mechanisms and Therapeutic Perspectives.

Journal of advanced research·2026

Related Experiment Video

Updated: Nov 29, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

7.8K

Preferential microglial activation associated with pathological alpha synuclein transmission.

Young Eun Kim1, Thuy Thi Lai2, Yun Joong Kim3

  • 1Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University, Anyang, South Korea.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|November 23, 2020
PubMed
Summary
This summary is machine-generated.

Parkinson's disease involves pathological α-synuclein. This study found that microgliosis, a type of brain inflammation, is linked to α-synuclein proliferation, suggesting microglia play a role in Parkinson's disease progression.

Keywords:
Alpha-synucleinAstrocyteInflammationMicrogliaParkinson’s disease

More Related Videos

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
08:33

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

Published on: June 25, 2019

8.5K
Technique for Intranasal Administration of &#945;-Synuclein Aggregates
04:49

Technique for Intranasal Administration of α-Synuclein Aggregates

Published on: November 8, 2024

788

Related Experiment Videos

Last Updated: Nov 29, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

7.8K
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
08:33

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

Published on: June 25, 2019

8.5K
Technique for Intranasal Administration of &#945;-Synuclein Aggregates
04:49

Technique for Intranasal Administration of α-Synuclein Aggregates

Published on: November 8, 2024

788

Area of Science:

  • Neuroscience
  • Pathology
  • Immunology

Background:

  • Parkinson's disease (PD) pathogenesis involves the self-proliferation of pathological α-synuclein.
  • Neuroinflammation is implicated in PD, but its association with α-synuclein spread remains unclear.

Purpose of the Study:

  • To investigate the relationship between neuroinflammation and α-synuclein propagation in the mouse striatum.
  • To evaluate microgliosis and astrogliosis in response to α-synuclein fibril injection.

Main Methods:

  • Injection of preformed α-synuclein fibrils into the mouse striatum.
  • Assessment of microgliosis and astrogliosis as indicators of neuroinflammation.

Main Results:

  • α-synuclein propagation was observed in the striatum following fibril injection.
  • Microgliosis was found to accompany α-synuclein propagation.
  • Astrogliosis did not show a similar association with α-synuclein proliferation.

Conclusions:

  • Microglia are preferentially associated with the proliferation of pathological α-synuclein.
  • This suggests a specific role for microglia in the spread of α-synuclein pathology in Parkinson's disease.