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Related Concept Videos

Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Preventive Healthcare Services01:30

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Related Experiment Video

Updated: Nov 29, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Is It the Era for Personalized Screening?

Carolina Rossi Saccarelli1, Almir G V Bitencourt2, Elizabeth A Morris3

  • 1Breast Imaging Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA; Department of Radiology, Hospital Sírio-Libanês, Rua Dona Adma Jafet 91, São Paulo, SP 01308-050, Brazil.

Radiologic Clinics of North America
|November 23, 2020
PubMed
Summary
This summary is machine-generated.

Personalized breast cancer screening is crucial, moving beyond a one-size-fits-all approach. This review covers current risk assessment and screening recommendations for all women, exploring future personalized strategies.

Keywords:
Breast cancerEarly detectionHigh riskMR imagingPersonalized medicineScreening

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Area of Science:

  • Oncology
  • Radiology
  • Preventive Medicine

Background:

  • Breast cancer screening significantly aids early detection, enhancing treatment effectiveness and lowering mortality rates.
  • A universal "one-size-fits-all" approach to breast cancer screening is increasingly recognized as inadequate.
  • Current guidelines primarily address very high-risk women, leaving average and higher-than-average-risk groups with uniform approaches.

Purpose of the Study:

  • To review current breast cancer risk assessment strategies.
  • To evaluate existing breast cancer screening recommendations for average-risk and higher-than-average-risk women.
  • To discuss emerging developments and future directions in personalized breast cancer screening.

Main Methods:

  • Literature review of current guidelines and research on breast cancer risk assessment.
  • Analysis of screening protocols for diverse risk groups.
  • Exploration of novel technologies and future trends in personalized screening.

Main Results:

  • Current screening practices often fail to account for individual risk variations beyond the very high-risk category.
  • Personalized risk assessment models are essential for tailoring screening protocols.
  • Advancements in imaging and risk prediction offer potential for more individualized screening.

Conclusions:

  • Tailoring breast cancer screening based on individual risk assessment is paramount for optimizing early detection and patient outcomes.
  • Future strategies should focus on integrating advanced risk prediction tools into routine screening protocols.
  • Personalized breast cancer screening promises to improve efficacy and reduce disparities in care.