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Updated: Nov 29, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
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Stereotactic Radiosurgery for Gynecologic Cancer

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Radiosurgery for Glioblastoma.

Adomas Bunevicius1, Jason P Sheehan1

  • 1Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA 22908, USA.

Neurosurgery Clinics of North America
|November 23, 2020
PubMed
Summary

Stereotactic radiosurgery (SRS) offers a precise radiation option for glioblastoma (GBM). Salvage SRS improves survival for recurrent GBM, and bevacizumab may enhance outcomes with SRS.

Area of Science:

  • Neuro-oncology
  • Radiation Oncology

Background:

  • Glioblastoma (GBM) presents significant treatment challenges with poor survival rates.
  • Stereotactic radiosurgery (SRS) provides precise, high-dose radiation delivery.

Purpose of the Study:

  • To evaluate the efficacy and safety of SRS in glioblastoma treatment.
  • To explore the role of salvage SRS and combination therapies.

Main Methods:

  • Review of clinical trials and treatment outcomes for GBM patients.
  • Analysis of salvage SRS versus surgical resection for recurrent GBM.
  • Investigation of upfront SRS versus fractionated radiation and the impact of bevacizumab with SRS.

Main Results:

  • Salvage SRS demonstrates improved survival and a better safety profile compared to re-operation for recurrent GBM.
Keywords:
Gamma knife radiosurgeryGlioblastomaPrognosisStereotactic radiosurgerySurvival

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  • Upfront SRS before fractionated radiation did not show benefits per RTOG 93-05.
  • Bevacizumab combined with SRS is linked to enhanced survival and dose escalation potential.

    • Conclusions:

    • Salvage SRS is a viable and safer option for recurrent glioblastoma.
    • Bevacizumab may improve outcomes when administered with SRS, potentially allowing for dose escalation.