Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Constraints and Statical Determinacy01:26

Constraints and Statical Determinacy

852
In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
852
Kinematic Equations: Problem Solving01:15

Kinematic Equations: Problem Solving

25.5K
When analyzing one-dimensional motion with constant acceleration, the problem-solving strategy involves identifying the known quantities and choosing the appropriate kinematic equations to solve for the unknowns. Either one or two kinematic equations are needed to solve for the unknowns, depending on the known and unknown quantities. Generally, the number of equations required is the same as the number of unknown quantities in the given example. Two-body pursuit problems always require two...
25.5K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

952
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
952
Linear Approximation in Time Domain01:21

Linear Approximation in Time Domain

216
Nonlinear systems often require sophisticated approaches for accurate modeling and analysis, with state-space representation being particularly effective. This method is especially useful for systems where variables and parameters vary with time or operating conditions, such as in a simple pendulum or a translational mechanical system with nonlinear springs.
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length,...
216
Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

3.9K
A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
3.9K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

188
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
188

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resolving parameter uncertainty in SIR models through population-level serological surveillance: A synthetic study.

Infectious Disease Modelling·2026
Same author

Systemic review of the relative age effect in Scottish schooling: a public health imperative for policy reform and equity.

BMJ public health·2026
Same author

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation.

NPJ digital medicine·2026
Same author

Contextual computation by competitive protein dimerization networks.

Cell·2026
Same author

Targeting a specific subset of neutrophils to mitigate cardiac reperfusion injury.

Research square·2026
Same author

A multiobjective optimization approach to data assimilation for complex biological systems with sparse data.

Mathematical biosciences·2025
Same journal

Microlocal analysis of non-linear operators arising in Compton CT.

Inverse problems·2026
Same journal

A PINN-driven game-theoretic framework in limited data photoacoustic tomography.

Inverse problems·2025
Same journal

An accelerated preconditioned proximal gradient algorithm with a generalized Nesterov momentum for PET image reconstruction.

Inverse problems·2025
Same journal

Method of moments for 3D single particle <i>ab initio</i> modeling with non-uniform distribution of viewing angles.

Inverse problems·2025
Same journal

Multi-target detection with application to cryo-electron microscopy.

Inverse problems·2025
Same journal

Linearized boundary control method for density reconstruction in acoustic wave equations.

Inverse problems·2024
See all related articles

Related Experiment Video

Updated: Nov 29, 2025

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator
06:45

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator

Published on: October 28, 2022

2.0K

Ensemble Kalman Methods With Constraints.

David J Albers1,2, Paul-Adrien Blancquart3, Matthew E Levine4

  • 1Department of Biomedical Informatics, Columbia University, New York, NY 10032.

Inverse Problems
|November 23, 2020
PubMed
Summary
This summary is machine-generated.

Ensemble Kalman methods offer a derivative-free approach for state and parameter estimation. This study introduces a general framework to incorporate prior information as constraints, enhancing estimation accuracy and applicability.

Keywords:
convex optimizationderivative-free optimizationensemble Kalman methodsequality and inequality constraints

More Related Videos

A Method for Tracking the Time Evolution of Steady-State Evoked Potentials
12:03

A Method for Tracking the Time Evolution of Steady-State Evoked Potentials

Published on: May 25, 2019

8.8K
Experimental Methods to Study Human Postural Control
08:12

Experimental Methods to Study Human Postural Control

Published on: September 11, 2019

9.9K

Related Experiment Videos

Last Updated: Nov 29, 2025

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator
06:45

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator

Published on: October 28, 2022

2.0K
A Method for Tracking the Time Evolution of Steady-State Evoked Potentials
12:03

A Method for Tracking the Time Evolution of Steady-State Evoked Potentials

Published on: May 25, 2019

8.8K
Experimental Methods to Study Human Postural Control
08:12

Experimental Methods to Study Human Postural Control

Published on: September 11, 2019

9.9K

Area of Science:

  • Computational mathematics
  • Data assimilation
  • Scientific computing

Background:

  • Ensemble Kalman methods are increasingly vital for state and parameter estimation.
  • Their derivative-free nature allows application with existing computational models.
  • Incorporating prior information (constraints) is crucial for many real-world problems.

Purpose of the Study:

  • To establish a general framework for enforcing prior information as constraints in Ensemble Kalman methods.
  • To develop a widely applicable methodology for constrained estimation.
  • To provide theoretical justification and numerical examples for the proposed framework.

Main Methods:

  • Development of a general mathematical framework for constrained estimation.
  • Formulation of a derivative-free methodology applicable to state-space models and parameter-to-observable maps.
  • Theoretical analysis to justify the proposed constrained estimation approach.

Main Results:

  • A widely applicable methodology for incorporating equality and inequality constraints into Ensemble Kalman filtering and smoothing.
  • Theoretical underpinnings demonstrating the validity of the constrained estimation approach.
  • Numerical experiments showcasing the effectiveness of the framework across various estimation problems.

Conclusions:

  • The proposed framework successfully integrates prior information as constraints into Ensemble Kalman methods.
  • This approach enhances the accuracy and reliability of state and parameter estimation.
  • The methodology is broadly applicable, offering significant advantages in scientific and engineering applications.