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Updated: Nov 29, 2025
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
A Systemic Literature Review and Meta-Analysis Reporting the Prevalence and Impact of Methicillin-Resistant
Canna Jagdish Ghia1, Shaumil Waghela1, Gautam Rambhad1
1Medical and Scientific Affairs, Pfizer Limited, Mumbai, India.
Aim And Objective:
This systematic review and meta-analysis was conducted to assess the prevalence, burden and epidemiology of methicillin-resistant S. aureus (MRSA). This systemic review was also aimed to highlight the challenges in the diagnosis and management of methicillin-resistant S. aureus (MRSA) in India (for all age groups). We also examined the published literature on the available treatment options and the role of prevention in the management of MRSA in India. By summarizing the currently available data, our objectives were to highlight the need for the prevention of MRSA infections and also emphasize the role of vaccination in the prevention of MRSA infections in India.
Methodology:
Electronic databases such as PubMed and databases of the National Institute of Science Communication and Information Resources and Indian Council of Medical Research Embase were searched for relevant literature published from 2005/01/01 to 2020/05/13 in English language, according to the predefined inclusion and exclusion criteria. A manual search was also conducted using the key term "MRSA 'or' Methicillin Resistant Staphylococcus aureus 'and' India." An independent reviewer extracted data from the studies using a structured Microsoft Excel spreadsheet, and a meta-analysis of proportion for MRSA prevalence with a corresponding 95% confidence interval (CI) for all included individual studies were performed.
Result:
A total of 34 studies involving 16 237 patients were included in the final meta-analysis. The pooled proportion of patients with MRSA infection was 26.8% (95% CI: 23.2%-30.7%). The MRSA infection was more prevalent among male patients (60.4%; 95% CI: 53.9%-66.5%) as compared to female patients (39.6%; 95% CI: 33.5%-46.1%), while the prevalence of MRSA was higher among adults (18 years and above; 32%; 95% CI: 5%-80%) in comparison to pediatric patients (0-18 years; 68%; 95% CI: 20%-94.8%). The degree of heterogeneity was found to be significant.
Conclusion:
The prevalence of MRSA in India was relatively high at 27% with a higher proportion observed among men aged >18 years. The high prevalence of MRSA infections in India necessitates the implementation of surveillance and preventive measures to combat the spread of MRSA in both hospital and community settings.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) infections are prevalent in India, affecting 27% of patients, particularly adult males. Enhanced surveillance and preventive strategies are crucial to control MRSA spread in healthcare and community settings.
Area of Science:
- Medical Microbiology
- Infectious Diseases Epidemiology
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant global health threat.
- Understanding the epidemiology and burden of MRSA in India is critical for effective public health interventions.
Purpose of the Study:
- To systematically review and meta-analyze the prevalence, burden, and epidemiology of MRSA in India.
- To identify challenges in MRSA diagnosis and management, and evaluate treatment and prevention strategies.
- To emphasize the need for MRSA prevention, including the potential role of vaccination.
Main Methods:
- Systematic review and meta-analysis of studies published between 2005 and 2020.
- Searched electronic databases (PubMed, NISCAIR, ICMR, Embase) and conducted manual searches using specific keywords.
- Data extraction by an independent reviewer and meta-analysis of MRSA prevalence proportions with 95% confidence intervals.
Main Results:
- Included 34 studies with 16,237 patients; pooled MRSA prevalence was 26.8% (95% CI: 23.2%-30.7%).
- MRSA was more prevalent in males (60.4%) than females (39.6%).
- Prevalence was higher in adults (32%) compared to pediatric patients (68%), with significant heterogeneity observed.
Conclusions:
- MRSA prevalence in India is high (27%), with a greater burden among adult males.
- Urgent implementation of surveillance and preventive measures is necessary in both hospital and community settings.
- Addressing MRSA requires a multi-faceted approach, including improved diagnostics, treatment, and prevention strategies.
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