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Updated: Nov 29, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection
Rafeed Rahman Turjya1, Md Abdullah-Al-Kamran Khan2, Abul Bashar Mir Md Khademul Islam1
1Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka, Bangladesh.
Background:
Regulatory roles of long noncoding RNAs (lncRNAs) during viral infection has become more evident in last decade, but are yet to be explored for SARS-CoV-2.
Materials & Methods:
We analyzed RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells to identify differentially expressed genes.
Results:
Our analyses uncover 21 differentially expressed lncRNAs broadly involved in cell survival and regulation of gene expression. These lncRNAs can directly interact with six differentially expressed protein-coding genes, and ten host genes that interact with SARS-CoV-2 proteins. Also, they can block the suppressive effect of nine microRNAs induced in viral infections.
Conclusion:
Our investigation determines that deregulated lncRNAs in SARS-CoV-2 infection are involved in viral proliferation, cellular survival, and immune response, ultimately determining disease outcome.
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