Related Experiment Video

Updated: Nov 29, 2025

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
08:13

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

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CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions

Pascal Leclair1, Chinten James Lim1

  • 1Department of Pediatrics, University of British Columbia, and, Michael Cuccione Childhood Cancer Research Program, B.C. Children's Hospital Research Institute, Vancouver, Canada.

Animal Cells and Systems
|November 23, 2020
PubMed

Insights

CD47 is a protein that helps tumors evade immune cells. This review explores how CD47 signaling causes cancer cell death, aiding new cancer therapies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • CD47 functions as a tumor-evasive mechanism by interacting with phagocytes.
  • Emerging evidence highlights CD47's role as a signaling receptor in cellular processes.

Purpose of the Study:

  • To comprehensively review CD47 signaling pathways involved in tumor cell death.
  • To explore the therapeutic potential of targeting CD47 for cancer treatment.

Main Methods:

  • Literature review of studies on CD47 signaling.
  • Analysis of CD47's role in immune evasion and cell death pathways.

Main Results:

  • CD47 ligation triggers specific signaling cascades leading to cancer cell death.
  • Understanding these pathways is crucial for developing effective CD47-based therapies.

Conclusions:

  • Targeting CD47 can simultaneously disarm its immune-evasive function and induce direct tumor cell death.
  • This dual-action strategy holds promise for improved anti-cancer therapeutics.
Keywords:
CD47antibodiescell deathpeptidesphagocytosis

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