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A single-center retrospective analysis of childhood hepatoblastoma in China
Wenya Yu1, Xiang Liu2, Jingquan Li1
1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Insights
Surgical therapy and male sex impact survival for pediatric hepatoblastoma (HB). Further research into the economic burden of childhood HB is recommended for improved health management.
Area of Science:
- Pediatric Oncology
- Health Economics
- Clinical Management
Background:
- Investigating critical prognostic factors for pediatric hepatoblastoma (HB) in China.
- Integrating health economics and management aspects into HB prognosis research.
Purpose of the Study:
- To identify key factors influencing survival in children diagnosed with hepatoblastoma.
- To analyze the economic implications and management strategies for pediatric HB.
Main Methods:
- Retrospective review of 87 pediatric HB cases (2013-2019).
- Descriptive analysis of patient characteristics.
- Kaplan-Meier and Cox proportional hazard models for survival and prognostic factor analysis.
Main Results:
- The 1- and 5-year survival rates for pediatric HB were 87.7% and 78.9%, respectively.
- Hepatectomy and liver transplantation significantly improved prognosis (HR: 0.039, 0.142).
- Male sex was associated with a poorer prognosis (HR: 3.614); average medical expenses were 40,217.5 CNY.
Conclusions:
- Survival rates for pediatric HB in China are comparable to global data.
- Surgical intervention and patient sex are significant prognostic indicators.
- The economic burden of pediatric HB warrants further comprehensive investigation.
Background:
This study aimed to investigate the critical factors associated with prognosis for children with hepatoblastoma (HB) in mainland China combined with the aspect of health economics and management.
Methods:
This study retrospectively reviewed children with HB in Renji Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine from January 2013 to December 2019. Descriptive analysis was used to describe the essential characteristics. Kaplan-Meier method and Cox proportional hazard models were used to estimate the survival rate and prognosis factors.
Results:
For the 87 children with HB, the average survival was 2,002.8 days (95% CI: 1,798.7-2,206.9 days), the 1- and 5-year survival rates were 87.7% and 78.9%, respectively. Undergoing surgery and sex were independent prognostic factors of childhood HB. Children with HB undergoing hepatectomy (HR: 0.039) or liver transplantation (HR: 0.142) had a better prognosis, while boys were associated with a poorer prognosis (HR: 3.614). The average medical expenses for childhood HB were 40,217.5±3,862.0 CNY and liver transplantation cost more than hepatectomy.
Conclusions:
The results had a comparable survival rate with other studies globally. Surgical therapy and sex are associated with the prognosis of children with HB. The economic burden of childhood HB deserves to be further explored.
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