Related Experiment Video
Updated: Nov 29, 2025
Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
Published on: January 10, 2025
Roles of TRAFs in Ischemia-Reperfusion Injury
Wei Zhou1, Danni Lin1,2, Zibiao Zhong1
1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Engineering Research Center of Natural Polymer-based Medical Materials in Hubei Province, Wuhan, China.
Abstract:
Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. These TRAF-dependent signaling pathways and physiological functions have been involved in the occurrence and progression of ischemia-reperfusion injury (IRI), which is a common pathophysiological process that occurs in a wide variety of clinical events, including ischemic shock, organ transplantation, and thrombolytic therapy, resulting in a poor prognosis and high mortality. IRI occurs in multiple organs, including liver, kidney, heart, lung, brain, intestine, and retina. In recent years, mounting compelling evidence has confirmed that the genetic alterations of TRAFs can cause subversive phenotype changes during IRI of those organs. In this review, based on current knowledge, we summarized and analyzed the regulatory effect of TRAFs on the IRI of various organs, providing clear direction and a firm theoretical basis for the development of treatment strategies to manipulate TRAF proteins or TRAF-dependent signaling pathways in IRI-related diseases.
Insights
Tumor necrosis factor receptor-associated factors (TRAFs) regulate intracellular processes and are implicated in ischemia-reperfusion injury (IRI). This review analyzes TRAF roles in various organ IRI, guiding future therapeutic strategies.
Area of Science:
- Molecular Biology
- Immunology
- Pathophysiology
Background:
- Tumor necrosis factor receptor-associated factor (TRAF) proteins are key intracellular signaling molecules.
- TRAF-dependent pathways are crucial in regulating biological processes.
- Ischemia-reperfusion injury (IRI) is a widespread pathophysiological condition with high mortality.
Purpose of the Study:
- To review and analyze the regulatory role of TRAF proteins in IRI across multiple organs.
- To provide a theoretical basis for developing TRAF-targeted therapies for IRI-related diseases.
Main Methods:
- Literature review and analysis of existing research on TRAFs and IRI.
- Synthesis of current knowledge on TRAF function in various organ IRI models.
Main Results:
- Genetic alterations in TRAFs significantly impact IRI phenotypes in organs like the liver, kidney, heart, lung, brain, intestine, and retina.
- TRAF proteins play a pivotal role in the occurrence and progression of IRI.
Conclusions:
- TRAF proteins are critical regulators of IRI.
- Understanding TRAF-mediated signaling pathways offers potential therapeutic targets for mitigating IRI and improving patient outcomes.
