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Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats
1Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, NJ 07901.
Brain Research
|December 1, 1987
Abstract:
Injection of the specific N-methyl-D-aspartate (NMDA) antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), into the frontal cortex of rats, induced hyperactivity characterized by unique episodic darting behavior. This behavioral profile contrasts sharply with the ataxia and hyperactivity seen after intracerebroventricular CPP and other NMDA antagonists.