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Updated: Nov 29, 2025
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
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Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species
Xiaoming Xie1,2, Tingting Zheng1, Wen Li1
1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Qianjing Avenue 2699, Changchun, 130012, China.
Macromolecular Rapid Communications
|November 23, 2020
Summary
Ionic coassembly of cationic peptides and anionic species creates advanced soft materials. This review highlights their hierarchical structures, properties, and applications in drug delivery and tissue engineering.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Supramolecular Chemistry
Background:
- Peptide assembly is crucial for hierarchical nanostructures and bioactive materials.
- Ionic coassembly, using cationic peptides and anionic species, is a key area of development.
- This approach offers advantages in creating functional soft materials.
Purpose of the Study:
- To systematically review recent progress in peptide-based ionic coassembly soft materials.
- To discuss the molecular design of cationic peptides and principles of ionic coassembly.
- To highlight the hierarchical structures, properties, and applications of these materials.
Main Methods:
- Review of literature on ionic coassembly of cationic peptides with various anionic species (small anions, polymers, polyoxometalates).
- Analysis of structure-property relationships in the resulting soft materials.
- Discussion of molecular design strategies for cationic peptides.
Main Results:
- Diverse combinations of cationic peptides and anionic species yield hierarchical structures.
- These coassembled materials exhibit unique properties and diverse applications.
- Emergent phenomena and findings in peptide-based ionic coassembly are illustrated.
Conclusions:
- Peptide-based ionic coassembly offers a versatile platform for advanced soft materials.
- The combination of peptide diversity and anionic species leads to unique characteristics.
- Potential applications span drug delivery, tissue engineering, gene transfection, and antibacterial agents.
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