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Diagnostic value of microRNAs for malignant pleural mesothelioma: A mini-review

Yan-Qiu Han1, Shang-Cheng Xu2, Wen-Qi Zheng1

  • 1Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.

Thoracic Cancer
|November 23, 2020
PubMed

Insights

Diagnosing malignant pleural mesothelioma (MPM) early is key. MicroRNAs show promise as accessible, non-invasive biomarkers for detecting this aggressive cancer, improving patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Malignant pleural mesothelioma (MPM) is an aggressive cancer with a poor prognosis.
  • Timely diagnosis of MPM is critical for improving patient outcomes.
  • Laboratory biomarkers offer advantages like low cost and reduced invasiveness for cancer diagnosis.

Purpose of the Study:

  • To review the diagnostic potential of microRNAs for malignant pleural mesothelioma.
  • To explore microRNAs as promising, minimally invasive biomarkers for MPM detection.

Main Methods:

  • Literature review of studies investigating microRNA in MPM diagnosis.
  • Analysis of microRNA expression in various sample types (tissue, circulation, body fluid).

Main Results:

  • MicroRNAs are non-coding RNAs regulating gene expression post-transcriptionally.
  • MicroRNA detection in different biological samples shows potential for diagnosing various disorders.
  • Evidence suggests microRNAs hold diagnostic value for MPM.

Conclusions:

  • MicroRNAs represent a promising class of biomarkers for MPM diagnosis.
  • The non-invasive nature and accessibility of microRNA detection could aid in early MPM identification.
  • Further research into microRNA biomarkers may enhance MPM diagnostic strategies.
Keywords:
Diagnosismalignant pleural mesotheliomamicroRNAreview

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