COVID-19 and cardiovascular diseases

Area of Science:

• Cardiology
• Infectious Diseases
• Public Health

Background:

• Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, presents a global health crisis.
• Beyond respiratory effects, COVID-19 severely impacts the cardiovascular system.
• Cardiovascular complications in COVID-19 patients are associated with high mortality rates.

Purpose of the Study:

• To review diverse clinical cardiovascular complications in COVID-19 patients.
• To explore the mechanisms underlying cardiovascular manifestations in SARS-CoV-2 infection.
• To emphasize the importance of integrating clinical and experimental findings for better patient management.

Main Methods:

• Literature review of clinical observations and experimental findings.
• Synthesis of data on cardiovascular manifestations in COVID-19.
• Analysis of potential pathogenic mechanisms involving systemic inflammation and ACE2 signaling.

Main Results:

• COVID-19 is linked to a wide spectrum of heart and vascular complications.
• Systemic inflammation plays a role in COVID-19-associated cardiovascular injury.
• Angiotensin-converting enzyme 2 (ACE2) signaling pathways are implicated in SARS-CoV-2 cardiovascular effects.

Conclusions:

• COVID-19 poses significant risks to the cardiovascular system.
• Further research integrating clinical and experimental data is needed to elucidate mechanisms.
• Improved understanding will facilitate timely identification and treatment of cardiovascular injury in COVID-19 patients.