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Related Experiment Video

Updated: Nov 29, 2025

Methods for Intravenous Self Administration in a Mouse Model
12:09

Methods for Intravenous Self Administration in a Mouse Model

Published on: December 8, 2012

54.6K

Aversion-resistant fentanyl self-administration in mice.

Sean C Monroe1, Anna K Radke2

  • 1Department of Psychology and Center for Neuroscience and Behavior, Miami University, 90 N Patterson Ave, Oxford, OH, 45056, USA.

Psychopharmacology
|November 23, 2020
PubMed
Summary
This summary is machine-generated.

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Researchers developed aversion-resistant oral fentanyl self-administration models in mice. These models show that mice continue to self-administer fentanyl even when adulterated with quinine, supporting addiction research.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Addiction Research

Background:

  • Animal models are crucial for understanding addiction mechanisms.
  • Existing models lack methods for studying aversion-resistant opioid use despite negative consequences.

Purpose of the Study:

  • To develop an aversion-resistant, oral fentanyl self-administration paradigm.
  • To investigate opioid-seeking behavior under aversive conditions.

Main Methods:

  • Mice were trained to self-administer oral fentanyl using two-bottle choice and operant tasks.
  • Quinine, a bittering agent, was added to fentanyl solutions at escalating concentrations.
  • Sucrose self-administration was also tested with quinine to establish detection thresholds.
Keywords:
AddictionCompulsiveMouseOpioidQuinine

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Related Experiment Videos

Last Updated: Nov 29, 2025

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08:39

Operant Sensation Seeking in the Mouse

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Main Results:

  • Mice consumed fentanyl despite the presence of quinine, indicating aversion resistance.
  • Quinine reduced sucrose consumption at higher concentrations, confirming detection.
  • Opioid self-administration was maintained even when quinine was introduced during training.

Conclusions:

  • Developed novel rodent models for studying aversion-resistant oral fentanyl self-administration.
  • These models demonstrate compulsive-like opioid-seeking behavior.
  • Validated paradigms for future research into the neural basis of addiction.