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Intestinal microbiome: a new target for chalaziosis treatment in children?

Mariaelena Filippelli1, Roberto dell'Omo2, Angela Amoruso3

  • 1Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Molise, Italy. oftelena@gmail.com.

European Journal of Pediatrics
|November 23, 2020
PubMed

Insights

Oral probiotics significantly reduced chalazion resolution time in children. This gut microbiome modification offers a safe and effective adjunctive therapy for ophthalmic conditions like chalaziosis.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Immunology

Background:

  • Intestinal dysbiosis is linked to various ophthalmic diseases.
  • The gut microbiome is a recognized therapeutic target for inflammatory eye conditions.
  • Probiotics are known for their role in pediatric health and disease prevention.

Purpose of the Study:

  • To investigate the efficacy of oral probiotics in treating chalaziosis in children.
  • To determine if specific probiotics can alter the clinical course and recurrence of chalaziosis.
  • To assess the impact of probiotic supplementation on the resolution time of chalazion.

Main Methods:

  • A prospective comparative pilot study involving 26 children with chalaziosis.
  • Participants were randomized into two groups: medical treatment alone versus medical treatment plus oral probiotics.
  • Probiotic group received a daily supplement containing Streptococcus thermophilus ST10, Lactococcus lactis LCC02, and Lactobacillus delbrueckii subsp. bulgaricus.

Main Results:

  • A significant difference in the time to complete chalazion resolution was observed, favoring the probiotic group.
  • Probiotic supplementation accelerated the resolution of chalazion compared to medical treatment alone.
  • No significant complications were reported in either treatment group.

Conclusions:

  • Modifying the intestinal microbiome with specific oral probiotics can positively impact chalaziosis in children.
  • Probiotic supplementation enhances traditional therapies, leading to faster chalazion resolution.
  • This approach offers a safe, feasible, and effective method to re-establish intestinal and immune homeostasis for ophthalmic health.

Keywords:
ChalaziosisChildrenMicrobiomeProbiotics

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