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Genetic Polymorphisms of PRNCR1 and Lung Cancer Risk in Chinese Northeast Population: A Case-Control Study and
Na Li1, Zhigang Cui2, Min Gao1
1Department of Epidemiology, School of Public Health, China Medical University, Shenyang, P.R. China.
DNA and Cell Biology
|November 23, 2020
Summary
Single-nucleotide polymorphisms (SNPs) in the long noncoding RNA prostate cancer-associated noncoding RNA 1 (PRNCR1) gene were investigated for lung cancer (LC) risk. Specific SNPs, rs13252298 and rs1456315, were found to be associated with increased LC risk in the Chinese population.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Long noncoding RNAs (lncRNAs) are implicated in cancer development and progression.
- The lncRNA Prostate Cancer-Associated Noncoding RNA 1 (PRNCR1) is a potential factor in various cancers.
Purpose of the Study:
- To investigate the association between three tag single-nucleotide polymorphisms (SNPs) in the PRNCR1 gene (rs13252298, rs1016343, and rs1456315) and lung cancer (LC) risk.
- To evaluate the association of these SNPs with overall cancer risk through meta-analysis.
Main Methods:
- A case-control study involving 576 LC patients and 612 cancer-free controls.
- Meta-analysis to assess the relationship between selected SNPs and overall cancer risk.
- Genotyping analysis to determine SNP associations with LC, nonsmall cell lung cancer (NSCLC), and lung adenocarcinoma.
Main Results:
- SNPs rs13252298 and rs1456315 showed a strong correlation with the risk of LC, NSCLC, and lung adenocarcinoma.
- Individuals with the GG genotype of rs13252298 had a significantly increased risk of LC (OR=1.565, p=0.015) and NSCLC.
- The GG genotype of rs1456315 was also associated with increased LC and NSCLC risk. Meta-analysis indicated rs1016343 and rs13252298 are associated with overall cancer risk, though rs1016343 lacked significance in Asians.
Conclusions:
- The SNPs rs13252298 and rs1456315 in the PRNCR1 gene may serve as genetic susceptibility factors for lung cancer in the Chinese population.
- Further research is required to validate these findings.
- PRNCR1 genetic variations warrant further investigation in lung cancer etiology.
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