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Hypoxia induced factor-1α levels in patients undergoing adenoidectomy

Kamile Yucel1, Isa Aydin2, Said Sami Erdem3

  • 1Medical Biochemistry, KTO Karatay University School of Health Sciences, Konya, Turkey.

Scandinavian Journal of Clinical and Laboratory Investigation
|November 23, 2020
PubMed

Insights

Children with adenoid hypertrophy (AH) have higher levels of hypoxia-induced factor-1α (HIF-1α). Higher HIF-1α correlates with adenoid-nasopharyngeal ratio (ANR), suggesting HIF-1α as a biomarker for hypoxia in AH.

Area of Science:

  • Pediatric Otolaryngology
  • Respiratory Physiology
  • Biomarker Research

Background:

  • Adenoid hypertrophy (AH) is a common cause of nasal congestion and hypoxia in children.
  • Hypoxia-induced factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia.

Purpose of the Study:

  • To investigate plasma HIF-1α concentrations in children with AH.
  • To explore the correlation between HIF-1α levels and the adenoid-nasopharyngeal ratio (ANR) in these patients.

Main Methods:

  • Plasma HIF-1α levels were measured using ELISA in 39 children with AH and 47 healthy controls.
  • HIF-1α concentrations were compared between groups and correlated with ANR and hemoglobin (Hb) levels.

Main Results:

  • Children with AH exhibited significantly higher serum HIF-1α levels compared to healthy controls (p=0.011).
  • A moderately significant positive correlation was found between HIF-1α and ANR (r=0.439, p=0.005) in patients with AH.
  • HIF-1α levels showed a significant positive correlation with Hb levels (r=0.542, p=0.000) in AH patients.

Conclusions:

  • Adenoid hypertrophy is associated with elevated HIF-1α levels, indicating hypoxia.
  • HIF-1α may serve as a potential biomarker for assessing hypoxia severity in pediatric AH.
  • The correlation between HIF-1α and ANR highlights the link between physical obstruction and physiological response.

Keywords:
Adenoids;adenoidectomy;hemoglobin;hypertrophy;hypoxia-inducible factor-1 alpha;hypoxia;receiver operating characteristics

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