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Hypoxia induced factor-1α levels in patients undergoing adenoidectomy
Kamile Yucel1, Isa Aydin2, Said Sami Erdem3
1Medical Biochemistry, KTO Karatay University School of Health Sciences, Konya, Turkey.
Scandinavian Journal of Clinical and Laboratory Investigation
|November 23, 2020
Summary
Children with adenoid hypertrophy (AH) have higher levels of hypoxia-induced factor-1α (HIF-1α). Higher HIF-1α correlates with adenoid-nasopharyngeal ratio (ANR), suggesting HIF-1α as a biomarker for hypoxia in AH.
Area of Science:
- Pediatric Otolaryngology
- Respiratory Physiology
- Biomarker Research
Background:
- Adenoid hypertrophy (AH) is a common cause of nasal congestion and hypoxia in children.
- Hypoxia-induced factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia.
Purpose of the Study:
- To investigate plasma HIF-1α concentrations in children with AH.
- To explore the correlation between HIF-1α levels and the adenoid-nasopharyngeal ratio (ANR) in these patients.
Main Methods:
- Plasma HIF-1α levels were measured using ELISA in 39 children with AH and 47 healthy controls.
- HIF-1α concentrations were compared between groups and correlated with ANR and hemoglobin (Hb) levels.
Main Results:
- Children with AH exhibited significantly higher serum HIF-1α levels compared to healthy controls (p=0.011).
- A moderately significant positive correlation was found between HIF-1α and ANR (r=0.439, p=0.005) in patients with AH.
- HIF-1α levels showed a significant positive correlation with Hb levels (r=0.542, p=0.000) in AH patients.
Conclusions:
- Adenoid hypertrophy is associated with elevated HIF-1α levels, indicating hypoxia.
- HIF-1α may serve as a potential biomarker for assessing hypoxia severity in pediatric AH.
- The correlation between HIF-1α and ANR highlights the link between physical obstruction and physiological response.
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