Differences in Persistently Elevated Hemoglobin A1c for African American and White Patients and the Role of Provider-Level Variation
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Updated: Nov 29, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Amy Cunningham1, John McAna2, Alexis Silverio1
1Department of Family and Community Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Abstract:
African Americans with type 2 diabetes (T2D) have higher average A1c levels than White patients. However, few studies have examined racial disparities in diabetes management in primary care, particularly provider-level variability. Study goals were to analyze racial differences for patients with any/2 or more elevated A1cs, explore patterns of visits/providers seen in patients with ≥1 elevated A1c, and explore the contributions of provider variability in patient A1c. A retrospective secondary analysis of electronic medical record data from a large urban health system was conducted, involving adult African American or White patients (ages18-65 years) with ≥2 measured A1cs between January 1, 2017-February 1, 2018. Descriptive statistics were calculated for demographic variables; paired t tests evaluated changes in A1c levels across the 2 most recent measurements, and a repeated measures ANOVA evaluated the impact of race on A1c changes. Logistic regression analyses examined the relationship of race with any elevated A1c levels and persistent A1c levels (≥ 2 consecutive A1c measurements ≥8.5). The intraclass correlation coefficient (ICC) estimated clustering of A1c by provider. A total of 1764 patients were included. African Americans were more likely to have any (odds ratio [OR] = 1.48, P < .001) and persistently elevated A1c (OR = 1.75, P = .0003). ICC was .27 for any elevated A1c and .32 for persistently elevated A1c. In primary care patients with T2D, African Americans were more likely than Whites to have any/persistently elevated A1c, with substantial variability attributable to the provider. Further research is needed to better understand patient- and provider-level contributors to A1c disparities.
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