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Motor control function of the prefrontal cortex.

P S Goldman-Rakic1

  • 1Section of Neuroanatomy, Yale University School of Medicine, New Haven, Connecticut 06510.

Ciba Foundation Symposium
|January 1, 1987
PubMed
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The prefrontal cortex, specifically the principal sulcus, plays a key role in motor control. Anatomical and behavioral studies show it influences delayed responses and directs motor centers.

Area of Science:

  • Neuroscience
  • Primate Behavior

Background:

  • The frontal lobe, comprising the prefrontal, premotor, and motor areas, is crucial for motor control.
  • The specific role of the prefrontal cortex in motor regulation has been less understood compared to other frontal areas.

Purpose of the Study:

  • To elucidate the circuit basis for the motor regulatory functions of the principal sulcus (Brodmann's area 9; Walker's area 46) within the prefrontal cortex.
  • To investigate the influence of the principal sulcus on delayed-response tasks in monkeys.

Main Methods:

  • Anatomical studies detailing reciprocal connections between the principal sulcus and other brain regions.
  • Behavioral and electrophysiological studies in Macaca mulatta (monkeys).

Main Results:

Related Experiment Videos

  • The principal sulcus exhibits reciprocal connections with supplementary motor and premotor fields, primary motor cortex, somatosensory areas, and motor thalamus.
  • Studies in monkeys demonstrated that the principal sulcus influences delayed-responding for both hand and eye movements.

Conclusions:

  • The prefrontal cortex, particularly the principal sulcus, has access to and can direct the output of multiple motor centers.
  • Evidence supports a significant role for the prefrontal cortex in motor control and regulation.