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Updated: Nov 29, 2025
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
Farhad Sarrafzadeh1, Seyed Mojtaba Sohrevardi2, Hamid Abousaidi1
1Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Background:
Antibiotic resistance is associated with longer hospitalizations, higher treatment costs, and increased morbidity and mortality rates.
Purpose:
This study aimed to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Iranian children.
Methods:
International databases, including Web of Science, PubMed, Embase, and Scopus, and Iranian databases, including Scientific Information Database (www.sid.ir), Magiran, and Iranian Database for Medical Literature (idml.research.ac.ir), were systematically searched for articles published between January 2000 and August 2019. Sources of heterogeneity were determined using subgroup analysis and meta-regression.
Results:
Overall, 343 studies were identified; of them, 20 were included in the meta-analysis to estimate the pooled prevalence. The pooled prevalence of MRSA was 42% (95% confidence interval [CI], 29-55) among culture-positive cases of S. aureus, 51% (95% CI, 39-62) in hospitalized children, and 14% (95% CI, 0.05-27) in healthy children.
Conclusion:
The overall pooled prevalence of MRSA in children was 42%. Appropriate infection control measures and effective antibiotic therapy are needed.
Insights
The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Iranian children was 42%. This highlights the need for robust infection control and effective antibiotic strategies to combat MRSA in pediatric populations.
Area of Science:
- Pediatric infectious diseases
- Microbiology
- Public health
Background:
- Antibiotic resistance poses significant challenges, including extended hospital stays, increased healthcare costs, and higher rates of illness and death.
- Methicillin-resistant Staphylococcus aureus (MRSA) is a major contributor to antibiotic resistance concerns globally.
Purpose of the Study:
- To determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) specifically within the pediatric population in Iran.
- To provide data on MRSA prevalence to inform public health strategies and clinical practices in Iran.
Main Methods:
- A systematic literature search was conducted across major international and Iranian databases (Web of Science, PubMed, Scopus, Embase, SID, Magiran, IDML).
- The search covered articles published from January 2000 to August 2019.
- Meta-analysis and meta-regression techniques were employed to synthesize data and identify sources of heterogeneity.
Main Results:
- A total of 343 studies were initially identified, with 20 studies ultimately included in the meta-analysis.
- The pooled prevalence of MRSA among culture-positive Staphylococcus aureus cases in children was 42%.
- Prevalence varied significantly: 51% in hospitalized children and 14% in healthy children.
Conclusions:
- The overall pooled prevalence of MRSA in Iranian children is 42%, indicating a substantial public health concern.
- Effective infection control measures are crucial to mitigate the spread of MRSA.
- Optimized antibiotic therapy is essential for managing MRSA infections in children.
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