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Stem cell-derived exosomes: Role in the pathogenesis and treatment of atherosclerosis

Hao Ling1, Ziyuan Guo1, Linlin Tan1

  • 1Department of Cardiology, Second Hospital of Jilin University, Chang Chun, 130012, China.

The International Journal of Biochemistry & Cell Biology
|November 23, 2020
PubMed

Insights

Atherosclerosis (AS) is a chronic inflammatory vascular disease. This review explores how stem cell-derived exosomes can offer novel therapeutic strategies for treating AS, improving clinical outcomes.

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Nanomedicine

Background:

  • Atherosclerosis (AS) is a chronic inflammatory vascular disease with high morbidity and mortality.
  • Current AS therapies are insufficient, necessitating novel treatment approaches.
  • Exosomes, particularly those derived from stem cells, show potential in regulating AS progression.

Purpose of the Study:

  • To review the pathological mechanisms of Atherosclerosis (AS).
  • To discuss the role of exosomes and stem cell-derived exosomes in AS.
  • To propose novel therapeutic strategies for AS using stem cell-derived exosomes.

Main Methods:

  • Literature review of Atherosclerosis (AS) pathology.
  • Analysis of exosome and stem cell-derived exosome functions in AS.
  • Synthesis of current research to propose therapeutic strategies.

Main Results:

  • AS involves complex processes including endothelial dysfunction, inflammation, smooth muscle cell proliferation, and macrophage activation.
  • Exosomes play a role in various AS processes.
  • Stem cell-derived exosomes demonstrate potential to overcome limitations in AS and stem cell therapy.

Conclusions:

  • Stem cell-derived exosomes represent a promising therapeutic avenue for Atherosclerosis (AS).
  • Further research into stem cell-derived exosomes could significantly improve clinical AS treatment.
  • Targeting AS with exosomes offers a novel strategy for managing this complex vascular disease.

Keywords:
AtherosclerosisExosomePathological processStem cellTherapy

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