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Platelet activation in rabbits with decompression sickness.

Phuc Hong Cao1, Bao Quoc Dang1, Thu Van Nguyen1

  • 1Department of Naval Medicine, Faculty of Military Occupational Medicine, Vietnam Military Medical University, Phuc La Commune, Ha Dong District, Ha Noi City, Vietnam.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|November 23, 2020
PubMed
Summary
This summary is machine-generated.

Decompression sickness (DCS) causes platelet activation, leading to decreased platelet counts and altered platelet shapes. This platelet activation is linked to survival time after DCS exposure.

Keywords:
decompression sicknessdiving medicineplatelet

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Area of Science:

  • Physiology
  • Hematology
  • Marine Biology

Background:

  • Platelets are sensitive to decompression sickness (DCS).
  • DCS can manifest as reduced platelet counts and circulating platelet microparticles.
  • Previous observations suggest platelets are significantly affected by DCS.

Purpose of the Study:

  • To investigate the hypothesis that DCS induces platelet activation within the bloodstream.
  • To quantify changes in platelet count and plasma markers post-DCS.
  • To examine morphological alterations in platelets following DCS exposure.

Main Methods:

  • The study involved 45 rabbits subjected to simulated dives.
  • Platelet counts and plasma platelet markers (PF4, BTG) were measured before and after DCS.
  • Scanning electron microscopy was used to analyze platelet morphology in a subset of rabbits.

Main Results:

  • Platelet count significantly decreased after DCS by approximately 13.49%, with a more pronounced reduction in severe DCS cases (-45.99%).
  • A correlation was observed between post-DCS platelet count and rabbit survival time.
  • While plasma markers PF4 and BTG showed no significant change at 30 minutes, scanning electron microscopy revealed significant platelet shape changes, including pseudopod formation and aggregation.

Conclusions:

  • The findings indicate clear evidence of platelet activation in the bloodstream during decompression sickness.
  • Morphological changes in platelets, rather than plasma marker concentration, are indicative of DCS-induced platelet activation at 30 minutes post-exposure.
  • Platelet count reduction and morphology changes serve as potential indicators of DCS severity and prognosis.