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Epstein-Barr Virus: How Its Lytic Phase Contributes to Oncogenesis
Quincy Rosemarie1, Bill Sugden1
1Department of Oncology, McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Microorganisms
|November 24, 2020
Summary
The Epstein-Barr Virus (EBV) lytic phase, not just the latent phase, drives cancer development. Its early gene products can trigger oncogenic pathways, aiding tumor growth and progression.
Area of Science:
- Oncology
- Virology
- Molecular Biology
Background:
- Epstein-Barr Virus (EBV) is linked to lymphoid and epithelial cancers.
- The EBV latent phase is traditionally associated with malignancy.
- Emerging evidence implicates the EBV lytic phase in cancer development.
Purpose of the Study:
- To review the role of the EBV lytic phase in oncogenesis.
- To summarize mechanisms of EBV lytic products in regulating oncogenic pathways.
- To highlight the potential for targeting the EBV lytic phase in cancer treatment.
Main Methods:
- Literature review of EBV's role in oncogenesis.
- Analysis of EBV lytic phase contributions to tumor formation and progression.
- Summary of molecular mechanisms involved.
Main Results:
- The EBV lytic phase contributes to oncogenesis via infectious particle production and regulation of cellular oncogenic pathways.
- Both complete and abortive lytic cycles can promote cancer.
- Early lytic gene products are key in regulating oncogenic pathways.
Conclusions:
- The EBV lytic phase is a significant factor in EBV-associated malignancies.
- Understanding these mechanisms can lead to novel therapeutic strategies.
- Targeting the EBV lytic phase offers a promising avenue for treating EBV-driven cancers.
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