Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

58.8K
Overview
58.8K
Phases of Wound Repair01:28

Phases of Wound Repair

7.3K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
7.3K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

6.6K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
6.6K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

7.2K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
7.2K
What is the Immune System?01:38

What is the Immune System?

122.5K
Overview
122.5K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

8.2K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease heterogeneity and molecular classification of inflammatory palmoplantar diseases.

The Journal of allergy and clinical immunology·2024
Same author

An aging-susceptible circadian rhythm controls cutaneous antiviral immunity.

JCI insight·2023
Same author

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity.

bioRxiv : the preprint server for biology·2023
Same author

Retraction notice to Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure J Allergy Clin Immunol Volume 145, Issue 5, May 2020, Pages 1389-1405.

The Journal of allergy and clinical immunology·2022
Same author

Editorial: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses.

Frontiers in immunology·2022
Same author

Thymic stromal lymphopoietin controls hair growth.

Stem cell reports·2022

Related Experiment Video

Updated: Nov 29, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

21.2K

The Cutaneous Wound Innate Immunological Microenvironment.

Stephen Kirchner1,2, Vivian Lei1,3, Amanda S MacLeod1,2,3,4,5

  • 1Department of Dermatology, Duke University, Durham, NC 27707, USA.

International Journal of Molecular Sciences
|November 24, 2020
PubMed
Summary
This summary is machine-generated.

The skin

Keywords:
innate immunityskinwounding

More Related Videos

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

9.7K
Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

19.1K

Related Experiment Videos

Last Updated: Nov 29, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

21.2K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

9.7K
Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

19.1K

Area of Science:

  • Immunology
  • Dermatology
  • Wound Healing

Background:

  • The skin acts as a crucial physical barrier against pathogens.
  • Wounds compromise skin integrity, necessitating robust repair and defense mechanisms.
  • The skin's immune microenvironment is vital for wound healing and pathogen protection.

Purpose of the Study:

  • To review the factors influencing the skin's immune microenvironment during wound repair.
  • To explore how the microbiome, neuroimmune signaling, environment, and age impact wound immunity.

Main Methods:

  • Literature review focusing on cutaneous immunology and wound healing.
  • Synthesis of current research on factors modulating the skin's immune response to injury.

Main Results:

  • The skin's immune microenvironment is dynamic and context-dependent.
  • Factors such as the microbiome, neuroimmune signals, environmental exposures, and host age significantly alter innate immune responses to wounding.
  • Immune cell recruitment and extracellular factor secretion are key components of wound repair and antimicrobial defense.

Conclusions:

  • Understanding the interplay of various factors is essential for effective wound management.
  • Modulating the cutaneous immune microenvironment holds therapeutic potential for improving skin barrier regeneration and defense.