Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stress and glucocorticoids in aging.

R Sapolsky1, M Armanini, D Packan

  • 1Department of Biological Sciences, Stanford University, California.

Endocrinology and Metabolism Clinics of North America
|December 1, 1987
PubMed
Summary

Aging involves reduced stress response efficiency and accelerated aging from chronic stress. Glucocorticoids damage the hippocampus, leading to hypersecretion, a cycle observed in rats but potentially linked to human aging pathologies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and experimental validation of a two-axis thrust stand for the characterization of electric thruster thrust vectoring.

The Review of scientific instruments·2025
Same author

Ion thrusters for electric propulsion: Scientific issues developing a niche technology into a game changer.

The Review of scientific instruments·2020
Same author

3D ion velocity distribution function measurement in an electric thruster using laser induced fluorescence tomography.

The Review of scientific instruments·2017
Same author

Effect of nanosecond pulsed electric field on Escherichia coli in water: inactivation and impact on protein changes.

Journal of applied microbiology·2014
Same author

Correlation between Bacillus subtilis scoC phenotype and gene expression determined using microarrays for transcriptome analysis.

Journal of bacteriology·2001
Same author

Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation.

The European journal of neuroscience·2001

Area of Science:

  • Gerontology
  • Neuroendocrinology
  • Stress Physiology

Background:

  • Aging is associated with decreased stress response efficiency.
  • Chronic stress may accelerate aging processes.
  • Adrenocortical function and glucocorticoid exposure are key components of stress response and chronic stress.

Purpose of the Study:

  • To examine the relationship between aging, stress response, and glucocorticoid function.
  • To investigate the role of glucocorticoids in hippocampal damage and aging.
  • To assess the relevance of these findings to human aging.

Main Methods:

  • Review of gerontologic literature on stress response and aging.
  • Analysis of studies on adrenocortical function and glucocorticoid exposure.

Related Experiment Videos

  • Examination of evidence for glucocorticoid-induced hippocampal damage in aging rats.

    • Main Results:

    • Glucocorticoids can damage the hippocampus over time.
    • Aging rats exhibit glucocorticoid hypersecretion linked to hippocampal damage.
    • This interaction forms a dysregulatory cascade in rat aging.
    • This cascade is not obligatory in normal human aging but may contribute to pathologies.

    Conclusions:

    • The glucocorticoid-hippocampal interaction supports theories of aging and stress.
    • This dysregulatory cascade is a normal aspect of aging in rats.
    • The findings suggest glucocorticoid excess is relevant to human aging pathologies, not normal aging.