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Updated: Nov 29, 2025

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
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Surface Acoustic Wave Sensor for C-Reactive Protein Detection.

Ming-Jer Jeng1,2, Mukta Sharma1, Ying-Chang Li3

  • 1Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan.

Sensors (Basel, Switzerland)
|November 24, 2020
PubMed
Summary
This summary is machine-generated.

This study presents a surface acoustic wave (SAW) sensor for detecting C-reactive protein (CRP). The developed sensor accurately quantifies CRP levels, showing potential for cardiovascular disease risk diagnosis.

Keywords:
C-reactive proteinpiezoelectric lithium niobatesurface acoustic wave

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Chemical Sensing

Background:

  • Investigated surface acoustic wave (SAW) sensor for C-reactive protein (CRP) detection using piezoelectric lithium niobate (LiNbO3) substrates.
  • Fabricated SAW sensor and performed immobilization for CRP/anti-CRP interaction to detect mass variations.

Discussion:

  • CRP/anti-CRP interaction induced mass variations, leading to detectable changes in sensor response amplitude (insertion loss).
  • Observed a minimum detectable CRP concentration of 0.1 μg/mL.
  • Established a linear relationship between insertion loss amplitude and CRP concentrations ranging from 0.1 μg/mL to 1 mg/mL.

Key Insights:

  • Demonstrated the feasibility of using SAW sensors for sensitive CRP detection.
  • Quantified CRP concentrations via changes in insertion loss amplitude.
  • Established a linear correlation between sensor response and CRP levels.

Outlook:

  • SAW sensors offer a promising platform for sensitive and quantitative CRP detection.
  • Potential application in cardiovascular disease risk diagnosis through accurate CRP level monitoring.
  • Further research could explore integration into point-of-care diagnostic devices.