Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials

Area of Science:

• Biomedical Engineering
• Materials Science
• Regenerative Medicine

Background:

• Biomaterials science is rapidly advancing, focusing on biocompatibility and mechanical properties.
• Current biomaterials can be enhanced with active targeting for precise cell-material interaction control.
• Natural structural macromolecules offer a foundation for developing next-generation biomaterials.

Purpose of the Study:

• To review recent advancements in biomaterials utilizing natural structural macromolecules.
• To highlight the integration of active targeting strategies, particularly aptamers, for enhanced functionality.
• To discuss aptamer-functionalized hybrid biomaterials for regenerative medicine and therapeutic delivery.

Main Methods:

• Review of literature on natural structural macromolecules in biomaterials.
• Analysis of biohybrid approaches for modifying macromolecules.
• Focus on aptamer conjugation and bioresponsive/bioactive systems.

Main Results:

• Natural macromolecules can be adapted for improved biomaterial performance.
• Biohybrid approaches enable the creation of functionalized biomaterials.
• Aptamer-functionalized hybrid biomaterials demonstrate significant potential in controlling cell-material interactions.

Conclusions:

• The integration of aptamer targeting with natural macromolecule-derived biomaterials is a promising frontier.
• These advanced biomaterials offer enhanced spatiotemporal control for biomedical applications.
• Future developments focus on bioresponsive and bioactive systems for regenerative medicine and drug delivery.