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Retinal insulin receptors. 2. Characterization and insulin-induced tyrosine kinase activity in bovine retinal rod
R J Waldbillig1, R T Fletcher, G J Chader
1Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, MD 20892.
Experimental Eye Research
|December 1, 1987
Abstract:
Bovine retinal rod outer segments (ROS) possess specific, high-affinity receptors for insulin. These receptors exhibit an insulin-stimulatable tyrosine-specific activity that is capable of phosphorylating the receptor's own beta-subunit and exogenous substrate. ROS insulin receptors exhibit heterogeneity in the apparent molecular weight of the receptor's alpha-subunit. In this regard, insulin receptors from this single cell type resemble insulin receptors obtained from whole retina, but are unlike receptors from brain and liver.