Related Experiment Video
Updated: Nov 29, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Potential anti-EBV effects associated with elevated interleukin-21 levels: a case report.
Kristian Assing1, Christian Nielsen2, Marianne Jakobsen2
1Department of Clinical Immunology, Odense University Hospital, J.B. Winsloevs Vej 4, 5000, Odense, Denmark. kristian.assing@rsyd.dk.
Elevated CD4+ T cell IL-21 levels in a patient with Epstein-Barr virus (EBV) disease may disrupt memory B cell formation, potentially aiding EBV control. This finding offers new insights into EBV pathogenesis.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- Epstein-Barr virus (EBV) establishes a persistent reservoir in memory B cells and plasma cells.
- Interleukin-21 (IL-21) plays a dual role, supporting B cell differentiation but also exhibiting anti-viral effects via CD8+ T cells.
- Understanding IL-21's role is crucial for managing EBV persistence and associated diseases.
More Related Videos
09:14Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
08:04Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014