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Management of mucus hypersecretion.

S W Clarke1

  • 1Department of Thoracic Medicine, Royal Free Hospital, London, England.

European Journal of Respiratory Diseases. Supplement
|January 1, 1987
PubMed
Summary
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Managing excessive mucus, or hypersecretion, involves various physical and pharmacological strategies. These methods aim to improve airway secretion clearance for conditions like chronic bronchitis and asthma.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Mucus hypersecretion (>25 ml/day) is characteristic of chronic bronchitis.
  • Bronchorrhea (>100 ml/day) is associated with asthma, bronchiectasis, and alveolar-cell carcinoma.
  • Effective airway secretion clearance is crucial for managing respiratory conditions.

Purpose of the Study:

  • To review physical and pharmacological methods for improving airway secretion clearance.
  • To evaluate the efficacy of different treatments for mucus hypersecretion and bronchorrhea.

Main Methods:

  • Review of physical therapies including chest physiotherapy (forced expiration technique, postural drainage) and oral high-frequency oscillation.
  • Analysis of pharmacological interventions such as beta-adrenergic drugs, methylxanthines, corticosteroids, anticholinergics, mucolytics, expectorants, hypertonic saline, and cromoglycate.

Related Experiment Videos

  • Consideration of airway obstruction and two-phase air-liquid flow dynamics.

    • Main Results:

    • Chest physiotherapy and oral high-frequency oscillation aid in clearing central and peripheral secretions.
    • Beta-adrenergic drugs and methylxanthines enhance secretion clearance, with effects beyond bronchodilation.
    • Corticosteroids are effective for bronchorrhea and asthma; anticholinergics may reduce hypersecretion.
    • Hypertonic saline shows utility, while the efficacy of traditional mucolytics and expectorants is less clear. Cromoglycate is beneficial in asthma.

    Conclusions:

    • A combination of physical and pharmacological approaches can effectively manage mucus hypersecretion and bronchorrhea.
    • Specific treatments like chest physiotherapy, certain bronchodilators, corticosteroids, and hypertonic saline offer significant benefits.
    • Further research may be needed to definitively establish the efficacy of mucolytics and expectorants.