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Upper respiratory tract secretions: pathophysiology.

N Mygind¹, S Brofeldt, B Ostberg

¹Department of Otorhinolaryngology, Rigshospitalet, Copenhagen, Denmark.

European Journal of Respiratory Diseases. Supplement

|January 1, 1987

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Nasal secretions, though less viscous than sputum, share similarities in composition. Watery nasal discharge can be effectively reduced by ipratropium, suggesting the nose as a model for airway secretion analysis.

Area of Science:

Otorhinolaryngology
Respiratory Medicine
Biochemistry

Background:

Nasal fluid is a complex mixture primarily from seromucous glands.
The anterior nose exhibits significant secretory activity, potentially independent of anterior serous glands.

Purpose of the Study:

To characterize the composition and properties of nasal secretions.
To investigate the pharmacological control of watery rhinorrhoea.

Main Methods:

Comparative analysis of nasal secretions and sputum.
Assessment of the effect of ipratropium on watery nasal discharge.

Main Results:

Nasal secretions exhibit lower viscosity, dry weight, and certain protein/sugar content compared to sputum, but similar albumin levels.

Related Experiment Videos

Watery rhinorrhoea is primarily reflex-mediated and responsive to anticholinergic treatment with ipratropium.

Purulent nasal discharge was not affected by ipratropium.

Conclusions:

Nasal secretions share characteristics with other airway secretions, indicating potential as a research model.
Ipratropium effectively reduces watery rhinorrhoea, highlighting the role of cholinergic pathways.
Further comparative studies of nasal and bronchial secretions are recommended.