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Pulmonary Manifestations of Skin Disorders in Children
Bernard A Cohen1, Nelson L Turcios2
1Division of Pediatric Dermatology, Johns Hopkins Medical Institutions, 200 N. Wolfe Street, Baltimore, MD 21287, USA.
Insights
Many pediatric skin conditions have associated lung problems. This overview covers pulmonary manifestations in children with various genetic and reactive skin disorders.
Area of Science:
- Pediatric Dermatology
- Pulmonology
- Genetics
Background:
- Systemic diseases frequently present with cutaneous findings.
- Pediatric conditions with significant skin manifestations often exhibit pulmonary involvement.
Purpose of the Study:
- To review the pulmonary manifestations associated with various pediatric skin disorders.
- To highlight the connection between dermatological and pulmonary systems in pediatric systemic diseases.
Main Methods:
- Literature review of inherited multisystem genetic disorders and reactive processes with cutaneous findings.
- Analysis of reported pulmonary manifestations in pediatric patients.
Main Results:
- Identified numerous pediatric skin conditions with significant pulmonary manifestations.
- Included inherited disorders (e.g., neurofibromatosis type 1, tuberous sclerosis complex) and reactive processes (e.g., mastocytosis).
Conclusions:
- Skin findings in pediatric patients can indicate underlying systemic diseases with pulmonary implications.
- Early recognition of cutaneous signs is crucial for diagnosing and managing associated pulmonary conditions.
Abstract:
Systemic diseases often manifest with cutaneous findings. Many pediatric conditions with prominent skin findings also have significant pulmonary manifestations. These conditions include both inherited multisystem genetic disorders such as yellow-nail syndrome, neurofibromatosis type 1, tuberous sclerosis complex, hereditary hemorrhagic telangiectasia, Klippel-Trénaunay-Weber syndrome, cutis laxa, Ehlers-Danlos syndrome, dyskeratosis congenita, reactive processes such as mastocytosis, and aquagenic wrinkling of the palms. This overview discusses the pulmonary manifestations of skin disorders.
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