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Primary biliary cholangitis with normal alkaline phosphatase: A neglected clinical entity challenging current

Benedetta Terziroli Beretta-Piccoli1, Guido Stirnimann2, Joachim Mertens3

  • 1Epatocentro Ticino, Via Soldino 5, 6900, Lugano, Switzerland.

Journal of Autoimmunity
|November 24, 2020
PubMed
Summary

This study found that primary biliary cholangitis (PBC) can be diagnosed histologically in patients with normal alkaline phosphatase (ALP) levels, even if anti-mitochondrial antibodies (AMA) are negative. Gamma-glutamyl transferase (GGT) may serve as a biomarker for treatment response in these cases.

Keywords:
Anti-mitochondrial antibodyAnti-nuclear antibody alkaline phosphataseGamma-glutamyltransferaseLiver histologyPrimary biliary cholangitis

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