Feasibility of developing children's Pill School within a UK hospital

Asia N Rashed1,2, David Terry3, Andy Fox4

  • 1Institute of Pharmaceutical Science, King's College London, London, London, UK asia.rashed@kcl.ac.uk.

Insights

A UK hospital trial found that children's Pill School (PS) training is feasible and acceptable. Most children successfully learned to swallow pills and were switched from liquid medicines.

Area of Science:

  • Pediatric medicine
  • Pharmaceutical sciences
  • Healthcare delivery

Background:

  • Many children require liquid medications, which can be challenging to administer and may have palatability issues.
  • Switching from liquid formulations to solid pills can improve medication adherence and simplify administration for pediatric patients.

Purpose of the Study:

  • To evaluate the feasibility and acceptability of a children's Pill School (PS) intervention in a UK hospital setting.
  • To determine the proportion of pediatric patients who can successfully transition from liquid medicines to pills.
  • To gather insights into children's and parents' experiences with the PS training.

Main Methods:

  • A cohort of 30 inpatient children (aged 3-18 years) on liquid medications suitable for pill formulation were enrolled.
  • Training sessions utilized progressively larger hard sweets to teach pill-swallowing techniques.
  • Data collected included training success rates, medication switch success, and participant feedback.

Main Results:

  • 87% of children mastered pill swallowing after a single training session (average 14.5 minutes).
  • 92% of participating children were discharged from the hospital taking pills.
  • Of 75 liquid medications assessed as switchable, 89% were successfully converted to pill form.

Conclusions:

  • The children's Pill School intervention is a feasible and acceptable method for teaching pediatric patients to swallow pills.
  • Successful pill swallowing and medication switching were achieved even in children as young as 3 years old.
  • This intervention offers a viable strategy to improve medication management in pediatric inpatients.
Abstract

Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...