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Coagulopathy in patients with COVID-19: a systematic review and meta-analysis

Xiaolin Zhang1, Xue Yang1, Hongmei Jiao1

  • 1Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.

Aging
|November 24, 2020
PubMed

Insights

Severe COVID-19 is linked to hypercoagulable coagulopathy. Key indicators like D-dimer and prothrombin time are elevated in severe cases, aiding in assessing COVID-19 illness severity.

Area of Science:

  • Medical research
  • Hematology
  • Infectious diseases

Background:

  • COVID-19 often presents with coagulation abnormalities and thrombotic events.
  • Understanding coagulopathy's role in COVID-19 severity is crucial for patient management.

Purpose of the Study:

  • To investigate the association between coagulopathy and COVID-19 severity.
  • To identify key coagulation parameters indicative of severe illness.

Main Methods:

  • Systematic literature search of multiple databases (PubMed, Embase, etc.) for studies published Dec 2019-May 2020.
  • Meta-analysis of coagulation parameters in 3,952 COVID-19 patients across 25 studies.
  • Statistical analysis using Stata14.0.

Main Results:

  • Severe COVID-19 patients showed significantly higher D-dimer, prothrombin time (PT), and fibrinogen (FIB) levels.
  • No significant differences were observed in platelet count or activated partial thromboplastin time (aPTT).
  • Elevated D-dimer, PT, and FIB correlate with increased COVID-19 severity.

Conclusions:

  • Hypercoagulable coagulopathy is associated with severe COVID-19 symptoms.
  • D-dimer, PT, and FIB are critical markers for evaluating coagulopathy in COVID-19 patients.
  • These findings can inform clinical assessment and management strategies for COVID-19.

Keywords:
COVID-19coagulationcoagulopathycoronavirusdisease severity

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