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Vitamin and mineral supplementation for β-thalassemia during COVID-19 pandemic
Annette d'Arqom1, Melvanda G Putri2, Yovani Savitri2
1Department of Pharmacology & Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia.
Aim:
Low levels of immune-related micronutrients have been identified in β-thalassemia samples. Moreover, the excess amount of iron, contributing to oxidative stress in the pathogenesis of the disease, alters the immune system in β-thalassemia, which is important during the COVID-19 pandemic.
Materials & Methods:
Searches of PUBMED and EMBASE were conducted to identify the level and supplementation of micronutrients in β-thalassemia, published from 2001-May 2020.
Results:
The review found six observational and five interventional studies supporting the importance of supplementing vitamins and minerals among patients with β-thalassemia.
Conclusion:
Supplementation of immune-related vitamins and minerals might bring benefits to the immune system, especially in reducing oxidative stress in β-thalassemia.
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