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Pathological angiogenesis and inflammation in tissues.

Ji-Hak Jeong1,2, Uttam Ojha1, You Mie Lee3,4

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Vascular-organ interactions are crucial for tissue homeostasis and disease, including cancer. Normalizing pathological angiogenesis presents a promising therapeutic strategy for various conditions.

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Area of Science:

  • Physiology
  • Immunology
  • Oncology

Background:

  • Angiogenesis is vital for organ development and tumor growth.
  • Vascular-organ interactions are key to understanding physiology and pathology.
  • Vascular endothelial cells function as innate immune cells influenced by pathological states.

Purpose of the Study:

  • To review the vascular contribution to microenvironment homeostasis in normal and cancerous tissues.
  • To explore vascular-organ interactions in physiological and pathological contexts.
  • To highlight pathological angiogenesis normalization as a therapeutic target.

Main Methods:

  • Literature review of angiogenesis and vascular-organ interactions.
  • Analysis of the role of vascular endothelial cells in innate immunity.
  • Examination of inflammatory cytokines in tissue pathogenesis.

Main Results:

  • Vascular contribution is a major factor in microenvironment homeostasis.
  • Pathological angiogenesis is implicated in various diseases, including cancer.
  • Inflammatory signaling critically affects tissue cells during disease.

Conclusions:

  • Vascular-organ interactions are central to tissue microenvironment regulation.
  • Normalization of pathological angiogenesis offers a potential therapeutic avenue.
  • Understanding vascular roles is essential for treating diseases like cancer.