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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Updated: Nov 29, 2025

Formation of Dispersible Taohong Siwu Tablets
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Oral Disintegrating Tablets - An Updated Patent Perspective.

Shailesh Sharma1, Kuljit Singh2

  • 1Department of Pharmaceutics, Pharmaceutical Research Division, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Ropar, Punjab, India.

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|November 24, 2020
PubMed
Summary
This summary is machine-generated.

Orodispersible tablets (ODTs) offer improved drug delivery, enhancing bioavailability and patient compliance, especially for pediatric and geriatric patients. This study reviews innovations in ODT formulation and manufacturing technologies.

Keywords:
DisintegrationFast Disintegrating Tablets (FDT)Orodispersible Tablets (ODT)lyophilizationsublimationsuperdisintegrants

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Conventional dosage forms face challenges like poor bioavailability, taste masking, and patient compliance.
  • Orodispersible tablets (ODTs) have emerged as a novel alternative, gaining significant attention over the past three decades.
  • ODTs dissolve rapidly on the tongue without water, benefiting patients with dysphagia, including pediatrics and geriatrics.

Purpose of the Study:

  • To review patent and non-patent literature on Orodispersible tablets (ODTs).
  • To analyze active ingredients, formulation techniques, and innovation outcomes within ODT development.
  • To provide insights into the advancements and market growth of ODTs.

Main Methods:

  • Comprehensive literature search focusing on patent and non-patent citations related to ODTs.
  • Analysis of various formulation and manufacturing technologies employed in ODT development.
  • Review of active pharmaceutical ingredients and their incorporation into ODTs.

Main Results:

  • Significant advancements in ODT formulation and manufacturing technologies have been observed in academia and industry.
  • Lyophilization, cotton candy, sublimation, melt extrusion, and direct compression are key technologies used in ODT production.
  • The ODT market has shown steady growth since the 1980s, with increasing product demand.

Conclusions:

  • ODTs represent a significant advancement in drug delivery, addressing limitations of conventional dosage forms.
  • Technological innovations continue to drive the development and market expansion of ODTs.
  • Further research and development in ODTs hold promise for improved therapeutic outcomes and patient convenience.