Oral Disintegrating Tablets - An Updated Patent Perspective

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems

Background:

• Conventional dosage forms face challenges like poor bioavailability, taste masking, and patient compliance.
• Orodispersible tablets (ODTs) have emerged as a novel alternative, gaining significant attention over the past three decades.
• ODTs dissolve rapidly on the tongue without water, benefiting patients with dysphagia, including pediatrics and geriatrics.

Purpose of the Study:

• To review patent and non-patent literature on Orodispersible tablets (ODTs).
• To analyze active ingredients, formulation techniques, and innovation outcomes within ODT development.
• To provide insights into the advancements and market growth of ODTs.

Main Methods:

• Comprehensive literature search focusing on patent and non-patent citations related to ODTs.
• Analysis of various formulation and manufacturing technologies employed in ODT development.
• Review of active pharmaceutical ingredients and their incorporation into ODTs.

Main Results:

• Significant advancements in ODT formulation and manufacturing technologies have been observed in academia and industry.
• Lyophilization, cotton candy, sublimation, melt extrusion, and direct compression are key technologies used in ODT production.
• The ODT market has shown steady growth since the 1980s, with increasing product demand.

Conclusions:

• ODTs represent a significant advancement in drug delivery, addressing limitations of conventional dosage forms.
• Technological innovations continue to drive the development and market expansion of ODTs.
• Further research and development in ODTs hold promise for improved therapeutic outcomes and patient convenience.