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Related Experiment Video

Updated: Nov 29, 2025

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Multi-wavelength, handheld laser speckle imaging for skin evaluation.

Michael Zieger1, Martin Kaatz1, Steffen Springer1,2

  • 1SRH Wald-Klinikum Gera GmbH, Zentrum für klinische Studien, Gera, Germany.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|November 24, 2020
PubMed
Summary

A new handheld laser speckle imaging device provides reproducible in vivo human skin evaluation. It successfully detected changes in skin aging, treatment effects, and basal cell carcinoma, showing its potential for clinical use.

Keywords:
basal cell carcinomahandheldlaser speckle imagingnon-invasive human skin diagnosticsskin ageing

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Area of Science:

  • Biomedical Optics
  • Dermatology
  • Medical Imaging Technology

Background:

  • Non-invasive in vivo human skin evaluation is crucial for diagnosing and monitoring various dermatological conditions.
  • Existing imaging technologies may have limitations in resolution, portability, or quantitative analysis.
  • Laser speckle imaging (LSI) offers a promising approach for assessing skin microcirculation and tissue properties.

Purpose of the Study:

  • To develop and qualify a handheld device for in vivo human skin evaluation using laser speckle imaging technology.
  • To assess the device's capability in detecting changes related to skin aging, therapeutic treatments, and disease diagnosis.

Main Methods:

  • Development of a handheld laser speckle device prototype with selectable laser wavelengths (400-800 nm).
  • Analysis of speckle pattern parameters including speckle contrast, size, modulation, and fractal dimension.
  • Evaluation of the device on three distinct skin conditions: aging, methyl nicotinate treatment response, and basal cell carcinoma.

Main Results:

  • The laser speckle imaging device yielded reproducible results across all investigated skin conditions.
  • Significant changes were observed in skin aging across three distinct age groups.
  • The device effectively quantified the effects of methyl nicotinate treatment, comparable to a moorFLPI device.
  • Significant differences were detected between normal and basal cell carcinoma-affected skin, despite a limited sample size.

Conclusions:

  • The developed handheld laser speckle imaging device demonstrates significant potential for in vivo skin evaluation.
  • The technology provides a viable method for objective and quantitative assessment of skin conditions.
  • Further applications in dermatology and clinical diagnostics are warranted based on these findings.