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Visual Function in Pentosan Polysulfate Sodium Maculopathy.

Riley J Lyons1, Judy Brower2, Nieraj Jain2

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|November 24, 2020
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Summary
This summary is machine-generated.

Pentosan polysulfate sodium (PPS) maculopathy significantly impairs vision beyond standard visual acuity tests. Advanced structural damage correlates with worse visual function, highlighting a critical patient safety concern.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Pharmacological Toxicity

Background:

  • Pentosan polysulfate sodium (PPS) is associated with maculopathy, presenting symptoms like prolonged dark adaptation and reading difficulties.
  • Standard visual acuity testing may not fully capture the extent of visual dysfunction in PPS maculopathy.

Purpose of the Study:

  • To investigate the degradation of visual function in patients with pentosan polysulfate sodium (PPS) maculopathy.
  • To determine if visual function deficits are adequately assessed by current visual acuity testing.

Main Methods:

  • Multimodal retinal evaluation including structural grading and functional testing.
  • Patient-reported outcomes using the National Eye Institute Visual Function Questionnaire 39 (NEI-VFQ-39) and Low Luminance Questionnaire (LLQ).
  • Objective functional assessments: ETDRS visual acuity, contrast sensitivity, microperimetry, and dark adaptometry, correlated with structural disease severity.

Main Results:

  • Thirteen patients (26 eyes) with a median age of 62 years were evaluated.
  • Functional testing revealed significant visual impairments, with median ETDRS visual acuity of 20/25.
  • Advanced structural disease correlated with significantly worse outcomes across multiple visual function tests.

Conclusions:

  • PPS maculopathy leads to substantial visual function loss not fully detected by best-corrected visual acuity (BCVA).
  • A strong correlation exists between objective visual function measures and disease severity.
  • These findings underscore a significant patient safety issue requiring further attention.