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Updated: Nov 29, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology.

Judith A Blake¹, Richard Baldarelli¹, James A Kadin¹

¹The Jackson Laboratory, Bar Harbor, ME, USA.

Nucleic Acids Research

|November 24, 2020

Summary

This summary is machine-generated.

The Mouse Genome Database (MGD) now offers enhanced tools for exploring mouse genomes, including more strains and variant data. These updates improve research into the genetic basis of human diseases and COVID-19.

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Area of Science:

Genomics
Bioinformatics
Comparative Genomics

Background:

The Mouse Genome Database (MGD) is a key resource for mouse genetics and genomics research.
It serves as an authoritative source for mouse gene, phenotype, and disease model data.
MGD supports comparative studies of human health and disease using the laboratory mouse.

Purpose of the Study:

To report significant enhancements to MGD's content and user interfaces.
To improve the exploration of mouse genomes and strain-specific data.
To facilitate research on mouse models for human diseases, including COVID-19.

Main Methods:

Enhancements to the Multi Genome Viewer for multi-strain genome exploration.
Expansion of mouse strain data, including new strain pages and extended query options.
Integration of comprehensive mouse strain variant data.

Main Results:

Improved visualization and querying capabilities for mouse genomic data.
Increased coverage of mouse strains and detailed information on their variants.
Streamlined literature curation processes and a new portal for COVID-19 research.

Conclusions:

MGD advancements provide more robust tools for genetic and genomic research.
The updated database facilitates deeper understanding of mouse models for human diseases.
Enhanced resources support ongoing biomedical research, including studies on infectious diseases like COVID-19.