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Updated: Nov 29, 2025
Monitoring the Wall Mechanics During Stent Deployment in a Vessel
Published on: May 8, 2012
Myocardial strain pattern progress in patients with Coarctation of the Aorta undergoing aortic stenting
Natalia Freitas de Deus Vale Aragão1, Juliana Nicchio Valentim Borgo2, Carlos Alberto de Jesus2
1Federal University of Vale do São Francisco (UNIVASF), Petrolina, Brazil.
Insights
Stenting for coarctation of the aorta (CoA) significantly improves left ventricular global longitudinal strain (LV GLS) over one year. Early intervention in younger patients may better preserve LV systolic function.
Area of Science:
- Cardiology
- Echocardiography
- Pediatric Cardiology
Background:
- Coarctation of the aorta (CoA) management requires sophisticated ventricular function assessment.
- Speckle tracking echocardiography reveals subclinical changes in ventricular function.
- The impact of CoA stenting on myocardial strain remains debated.
Purpose of the Study:
- To evaluate changes in left ventricular global longitudinal strain (LV GLS) after aortic stenting in CoA patients.
- To assess the correlation between LV GLS and pre-intervention factors.
Main Methods:
- 21 CoA patients and 21 controls underwent echocardiography before and 6-12 months post-stenting.
- Left ventricular global longitudinal strain (LV GLS) was measured.
- Correlations with gradients, age at intervention, LV mass, and ejection fraction were analyzed.
Main Results:
- CoA patients had lower baseline LV GLS compared to controls (P < .01).
- LV GLS significantly improved 6 and 12 months post-stenting (P < .001).
- Pre-intervention LV GLS correlated negatively with age at intervention (P = .007).
Conclusions:
- Percutaneous stenting improves LV GLS in CoA patients within 12 months.
- Older age at intervention is associated with lower LV GLS.
- Early intervention may be crucial for preserving left ventricular systolic function.
Background And Aim:
Ventricular function evaluation in coarctation of the aorta (CoA) has become more sophisticated and precise with speckle tracking, revealing subclinical changes. However, CoA stenting treatment effects in on myocardial strain are still controversial. This study aimed to estimate the extent to which changes in left ventricular global longitudinal strain (LV GLS) occur in patients with CoA who undergo stenting.
Methods:
The study included 21 patients with CoA (median age: 15 years [8-39]) and 21 healthy individuals matched by age and gender. Clinical and echocardiographic evaluations were performed 1 day before, 6 months, and 1 year after stenting. Correlations between LV GLS and arm-leg gradient, isthmus gradient on echocardiogram, age at intervention, left ventricular mass, and ejection fraction were tested.
Results:
Before treatment, patients with CoA had lower LV GLS than the control group (-18.4% ± 1.96 vs -21.5% ± 1.37; P < .01), showing significant increase to -19.4% ± 2.1 at 6 months and -20.7% ± 2.19 at 1 year, P < .001. Only 28.5% (6 patients) had preserved GLS before treatment, improving to 80.9% (17 patients) in 1 year. The only variable correlated with low LV GLS values before treatment was age at intervention (Spearman's index = -0.571; P = .007).
Conclusion:
Percutaneous therapy showed significant LV GLS improvement 12 months after aortic stenting. Older patients have lower GLS, suggesting that early intervention may have positive effects on preservation of LV systolic function.
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