Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Heart01:20

Anatomy of the Heart

1.7K
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
1.7K
Anatomy of the Heart01:27

Anatomy of the Heart

116.6K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
116.6K
Chambers of the Heart01:16

Chambers of the Heart

9.2K
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
9.2K
Heart Valves01:16

Heart Valves

10.0K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
10.0K
Development of the Heart01:27

Development of the Heart

1.7K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
1.7K
Overview of the Heart01:07

Overview of the Heart

11.7K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
11.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed Cutibacterium acnes infection of a thoracic aortic graft presenting as empyema: A case report and literature review.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same author

Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

[Experience with Mucoepidermoid Carcinoma of the Floor of the Mouth Detected Early during Remote Island Oral Cancer Screening in Kagawa Prefecture].

Gan to kagaku ryoho. Cancer & chemotherapy·2025
Same author

Antimicrobial use in pediatric patients: a subgroup analysis of the 2020 point prevalence survey in Aichi, Japan.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2025
Same author

Antimicrobial use in Japanese hospitals: results from a point-prevalence survey in Aichi, 2020.

The Journal of hospital infection·2025
Same author

Appropriate excision surgery reduces intrahepatic bile duct dilatation in pediatric patients with congenital biliary dilatation.

Pediatric surgery international·2025

Related Experiment Video

Updated: Nov 29, 2025

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

4.7K

Making the Right Loop for the heart.

Yukio Saijoh1, Hiroshi Hamada2

  • 1Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, USA.

Developmental Cell
|November 24, 2020
PubMed
Summary
This summary is machine-generated.

Left-right asymmetric Nodal signaling guides the developing heart tube through its characteristic rightward looping. This study reveals molecular mechanisms controlling early heart development and chamber formation.

More Related Videos

Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption
12:43

Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption

Published on: August 16, 2016

20.7K
3D Whole-heart Myocardial Tissue Analysis
06:53

3D Whole-heart Myocardial Tissue Analysis

Published on: April 12, 2017

9.1K

Related Experiment Videos

Last Updated: Nov 29, 2025

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

4.7K
Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption
12:43

Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption

Published on: August 16, 2016

20.7K
3D Whole-heart Myocardial Tissue Analysis
06:53

3D Whole-heart Myocardial Tissue Analysis

Published on: April 12, 2017

9.1K

Area of Science:

  • Developmental biology
  • Cardiovascular research
  • Molecular signaling

Background:

  • The developing heart initiates as a straight tube.
  • This structure undergoes a critical process known as rightward looping.
  • Understanding the regulation of this early cardiac morphogenesis is vital.

Purpose of the Study:

  • To elucidate the role of left-right asymmetric Nodal signaling in regulating heart looping.
  • To identify the molecular pathways involved in cardiac left-right asymmetry.

Main Methods:

  • Investigated Nodal signaling pathways in embryonic heart development.
  • Utilized genetic and imaging techniques to observe heart tube morphogenesis.
  • Analyzed the effects of manipulating Nodal signaling on heart looping direction.

Main Results:

  • Demonstrated that asymmetric Nodal signaling is essential for correct rightward heart looping.
  • Identified specific molecular components downstream of Nodal that mediate this process.
  • Showed that disruption of Nodal asymmetry leads to abnormal heart tube orientation.

Conclusions:

  • Left-right asymmetric Nodal signaling is a key regulator of embryonic heart looping.
  • This signaling pathway plays a crucial role in establishing cardiac left-right asymmetry.
  • Findings provide insights into the molecular basis of congenital heart defects related to looping abnormalities.