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An R-shiny application to calculate optimal designs for single substance and interaction trials in dose response

T Holland-Letz1, A Kopp-Schneider1

  • 1German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Toxicology Letters
|November 24, 2020
PubMed
Summary

This study introduces a user-friendly application for optimal experimental design in dose-response studies. It simplifies the calculation of D-optimal designs for single and multiple substance interactions, enhancing precision in parameter estimation.

Keywords:
Combination indexD-optimal designDose–response studiesOptimal experimental designR-shinyWeb application

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