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Updated: Nov 28, 2025

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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Epigenetics in β-cell adaptation and type 2 diabetes

Hyunki Kim1, Rohit N Kulkarni1

  • 1Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.

Current Opinion in Pharmacology
|November 24, 2020
PubMed
Summary

Epigenetic changes, not DNA sequence variations, are crucial for pancreatic beta-cell function and adaptation. Understanding these epigenetic mechanisms is key to addressing type 2 diabetes prevalence.

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