Electrodialysis with porous membrane for bioproduct separation: Technology, features, and progress

Area of Science:

• Membrane Science and Technology
• Biochemical Engineering
• Separation Processes

Background:

• Electrodialysis with porous membrane (EDPM) integrates electrodialysis (ED), porous filtration membranes, and electrophoresis.
• It shows potential for separating, purifying, and concentrating bioactive components.

Purpose of the Study:

• To provide a comprehensive overview of recent advancements in EDPM technology.
• To discuss principles, configurations, mathematical modeling, optimization, fouling, and applications of EDPM.
• To compare EDPM with other preparative electrophoresis-based separation technologies.

Main Methods:

• Literature review of EDPM studies.
• Analysis of EDPM principles, configurations, and mathematical models.
• Evaluation of process optimization, membrane fouling, and applications.
• Comparison with other large-scale preparative electrophoresis techniques.

Main Results:

• EDPM is a promising technology but faces limitations such as low productivity, membrane fouling, and difficulties with high molecular weight components.
• Existing studies have attempted to optimize EDPM performance, but significant challenges remain for full-scale implementation.
• Other electrophoresis-based separation technologies also have limitations for large-scale applications.

Conclusions:

• EDPM technology has considerable potential but requires further development to overcome current drawbacks.
• Addressing issues like productivity and fouling is crucial for the widespread adoption of EDPM.
• Future research should focus on prospective developments to enable full-scale applications of EDPM.